Yamaha HS80M Monitors

[boyd]

I've gone over all the monitors threads and loads of reviews, just wanted to ask a bit more specifically about these yamahas, as they seem good for the price compared to others around £300-400.

My worry is they'll be too big and beefy/powerful for my small bedroom, would this matter? I would go for the smaller HS50Ms but the bass response isn't as low, and I don't really want to have to get a sub. I see the other alternative as KRK Rokit RP6s, but I've read quit a lot of negative things about them.

So yeah bit stuck here, want to make the right choice for first monitors! Any advice appreciated.

[legend4ry]

I've gone over all the monitors threads and loads of reviews, just wanted to ask a bit more specifically about these yamahas, as they seem good for the price compared to others around £300-400.

My worry is they'll be too big and beefy/powerful for my small bedroom, would this matter? I would go for the smaller HS50Ms but the bass response isn't as low, and I don't really want to have to get a sub. I see the other alternative as KRK Rokit RP6s, but I've read quit a lot of negative things about them.

So yeah bit stuck here, want to make the right choice for first monitors! Any advice appreciated.

can't say about the monitors but you don't "reallllllly" need a sub anyways, my monitors go down to 70 and my tunes sound nice on a big system cause its like... what 30-40 hertz what are not being heard unless its on the bigger systems in the country/world ? Don't think my tunes suffer immensely because of it, plus I always check on headphones after just to make sure theres shit going on below the knock off point.

Then again believe it or not from being into this sound for ages... I don't even 'really' like really deep sub bass would rather hear something than feel it so my opinions bollocks.

[Disco Nutter]

I use HS-50's and I'm quite happy with them to be honest

[relaxotan]

i have them, they sound pretty tight, very accurate, and they look very very nice!!

my room is 5m by 4 m and they're not too loud or anything.

[jobbanaught]

Go get 'em, for me it was the bet investment in years. Love those speakers seriously!

If your room is small and all that, try some of those:

http://www.primacoustic.com/recoil-home.htm
http://www.gearslutz.com/board/so-much- ... lizer.html

They are expensive, but for me they work wonders to tame the sometimes overwhelming bass. Sounds much more defined now in my 2,50 * 3,50 m room. And no, im not some kind of geek to spend x amounts of Eur for gear, they really work wonders (would have returned them otherwise )

[boyd]

Thanks for the replies, gonna get them i think

[bjzyxty]

宫颈癌致病机理
人类乳头瘤病毒（ HPV ）感染在宫颈癌病因中具有重要作用。在浸润前或浸润期宫颈癌中存在 HPV16 、 18 、 31 和 33 型，宫颈良性扁平疣中存在 HPV6 和 11 型。美国 513 例宫颈癌患者的两年随访发现 HPV 感染消退者为 25 ％，持续不变者为 60 ％，加重者为 14 ％。几个癌基因对宫颈癌的发生是有关的，如 c-myc 基因过度表达，远处转移的危险性估计增加了 6 倍， ras 基因表达增加与淋巴结转移有关。
宫颈癌常呈局部扩散和淋巴结转移，肿瘤蔓延至阴道上段、宫旁、膀胱和直肠是最常见的部位。宫颈癌早期可向外侧和后方延伸，累及主韧带和宫骶韧带。肿瘤扩展至宫旁，一侧或双侧输尿管阻塞，导致肾盂积水和尿毒症是常见的晚期症状。晚期病例可直接扩散至膀胱或直肠，肿瘤浸润或穿透可导致腹腔内扩散和侵犯小肠。

一旦发生淋巴血管浸润，肿瘤栓可进入宫旁、盆腔、主动脉旁淋巴结。晚期病例通过胸导管可累及左侧锁骨上淋巴管。淋巴管阻塞可导致双侧淋巴管水肿和转移至腹股沟和外生殖器。血运扩散是直接由毛细血管或浸润或通过交通的淋巴血管间隙引起。

（ 1 ）与性生活、婚姻、妊娠的关系 性生活过早（指 18 岁前即有性生活）的妇女，其宫颈癌的发病率较 18 岁以后开始性生活的要高 4 倍。若妇女性生活开始早，有患有梅毒、淋病等性传播疾病，则其宫颈癌的发病率将较正常妇女高 6 倍。已证实若妇女与多个男子发生性关系，其发生宫颈癌的机会较多。这可能是青春期前的妇女，下生殖道尚未成熟，对致癌因素的刺激比较敏感，若较早开始性生活，一旦被某些细菌或病毒感染后，容易引发癌症。
（ 2 ）宫颈癌外源因素
犹太人宫颈癌发病率低，研究其原因可能与犹太人的风俗是男婴出生后需切除包皮有关。但也有认为在未切除包皮的犹太人群中，妇女患宫颈癌者也少见。目前尚缺乏实验资料证实包皮切除能减少宫颈癌的发生，虽然 Nahmos 曾从男子的包皮垢中分离出 HSV-2 型病毒。 Singer （ 1976 ）等曾提出精子头部所含的组蛋白和精蛋白是一种致癌因素，可作用于宫颈化生细胞的 DNA 细丝。 Coppelson 及 Reid 等认为成年妇女特别在妊娠期，鳞化活跃的宫颈上皮最容易恶变，这可能与 DNA 病毒有关。当然精子本身在特殊情况下也会对宫颈起诱变作用，这些新的假设尚待进一步证实。
（ 3 ）内分泌因素
性激素是否会促进宫颈癌的发生也是多年来研究的问题。动物实验用雌激素诱导小鼠发生鳞癌已获得成功，但在人体用外源性雌激素诱发宫颈癌尚未获得确实证据。

（ 4 ）性传播性疾病
60 年代以前认为梅毒患者的宫颈癌发生率高，但至今尚未找到梅毒引起宫颈癌的直接证据。滴虫性阴道炎常与宫颈癌前病变或宫颈癌并存。 Parfen 等发现宫颈不典型增生合并滴虫性阴道炎者，其转化为浸润癌的机会增加，并已成功地用滴虫感染动物，诱发出宫颈癌。但两者都为性传播疾病，可以并存，且宫颈不典型增生患者的阴道酸碱度常偏于碱化，有利于滴虫生长，故不能证实滴虫感染可诱发宫颈癌。