Pie & Mash Appreciation

[christophera]

the number 1 thing about pot that none of these studies acknowledges is that it makes you less susceptible to brainwashing.

potheads are less brainwashed. that is why this wonder drug is illegal.

if it made you dumb and gullible and die sooner, it would be on billboards from sea to shining sea

[elbe]

what i'm saying is that if pot bothers you, it's your problem and not the pot-user's.

would agree with that.


though a lot of what you quote previously is talking about the medical benefits of the hemp plant, or parts of it. This is a completely different matter to smoking weed.

esp issue with the morality/cancer thing, smoking anything will increase your chances of lung/mouth/throat cancer, even if it has benefits it will not outweigh the negatives,....and yet I still smoke cigs like a trooper.

[christophera]

basically pot is good for you.

this thread may as well be about being addicted to organic bananas

[christophera]

smoking pot doesn't cause cancer. it prevents cancer.

[gwa]

No I can't get enough of the stuff. It just seems to aid any situation IMO. Like once you get passed the I'm super fucking stoned monged out of my face cant do anything as i cant interact. It then becomes great.

Plus stoned sex FTW.

[elbe]

smoking pot doesn't cause cancer. it prevents cancer.

[christophera]

learn how to read, tiger.

pot prevents cancer.

[christophera]

For Three Decades, Politicians and Bureaucrats Have Ignored
Research On Marijuana's Role In Cancer Prevention
By Paul Armentano
Special to Betterhumans
10/6/2004 3:10 PM

http://betterhumans.com/Features/Column ... 04-10-06-1

Credit: Paul Armentano
Cannabis cover-up: Since 1974, says NORML Foundation analyst Paul Armentano, the US government has turned a blind eye to research on marijuana's anticancer properties

Clinical research published recently in the journals Cancer Research and BMC Medicine touting the ability of cannabis to stave the spread of certain cancers is the latest in a three-decade long line of studies demonstrating pot's potential as an anticancer agent.

Not familiar with this research? You're not alone.

For more than 30 years, US politicians and bureaucrats have turned a blind eye to any and all science indicating that marijuana may play a role in cancer prevention, a finding that was first documented as early as 1974. That year, a research team at the Medical College of Virginia (acting at the behest of the federal government, which must preapprove all US research on marijuana) discovered that cannabis inhibited malignant tumor cell growth in culture and in mice. According to the study's results, reported nationally in an August 18, 1974, Washington Post newspaper feature, marijuana's psychoactive component THC, "slowed the growth of lung cancers, breast cancers and a virus-induced leukemia in laboratory mice, and prolonged their lives by as much as 36 percent."

Despite these favorable preliminary findings, US government officials dismissed the study (which was eventually published in the Journal of the National Cancer Institute in 1975), and refused to fund any follow-up research until conducting a similar—though secret—clinical trial in the mid-1990s. That study, conducted by the US National Toxicology Program to the tune of two million dollars, concluded that mice and rats administered high doses of THC over long periods had greater protection against malignant tumors than untreated controls.

Rather than publicize their findings, government researchers once again shelved the results, which only came to light after a draft copy of the findings were leaked in 1997 to a medical journal which in turn forwarded the story to the national media.

Nevertheless, in the eight years since the completion of the National Toxicology trial, the US government has yet to encourage or fund additional, follow-up studies examining the drug's potential to protect against the spread of cancerous tumors.

Foreign findings

Fortunately, scientists overseas have generously picked up where US researchers so abruptly left off. In 1998, a research team at Madrid's Complutense University discovered that THC can selectively induce programmed cell death in brain tumor cells without negatively impacting surrounding healthy cells. Then in 2000, they reported in the journal Nature Medicine that injections of synthetic THC eradicated malignant gliomas (brain tumors) in one-third of treated rats, and prolonged life in another third by six weeks.

Last year, researchers at the University of Milan in Naples, Italy, reported in the Journal of Pharmacology and Experimental Therapeutics that non-psychoactive compounds in marijuana inhibited the growth of glioma cells in a dose-dependent manner, and selectively targeted and killed malignant cells through a process known as apoptosis.

More recently, researchers reported in the August 15, 2004 issue of Cancer Research, the journal of the American Association for Cancer Research, that marijuana's constituents inhibited the spread of brain cancer in human tumor biopsies. In a related development, a research team from the University of South Florida further noted that THC can also selectively inhibit the activation and replication of gamma herpes viruses. The viruses, which can lie dormant for years within white blood cells before becoming active and spreading to other cells, are thought to increase one's chances of developing cancers such as Kaposi's Sarcoma, Burkitt's lymphoma and Hodgkin's disease.

Regrettably, US politicians have been little swayed by these results, and remain steadfastly opposed to the notion of sponsoring—or even acknowledging—this growing body of clinical research. Their stubborn refusal to do so is a disservice not only to the scientific process, but also to the health and well being of America's citizenry.

Nonetheless, it appears that their silence will be unable to put this genie back in the bottle, as overseas research continues to move forward at a staggering pace. Writing this month in the journal of the American Society of Hematology, researchers at Saint Bartholomew's Hospital in London reported that THC induces cell death (apoptosis) in three leukemic cell lines. Authors further noted that the cannabinoid appears to function in manner different than standard chemotherapeutic agents such as cisplatin, and begins taking effect within mere hours after administration.

Swiss researchers are also weighing in on the use of cannabinoids' anticancer properties, reporting in a recent study published in the Journal of Neuropathology and Experimental Neurology that endogenous cannabinoids (naturally occurring compounds in the body that bind to the same receptors as the cannabinoids in marijuana) induced apoptosis in long-term and recently established glioma cell lines. Even more notably, a review article published last month in the journal Neuropharmacology concluded that cannabinoids' ability to selectively target and kill malignant cells set the basis for their potential use in the management of various types of cancers.

Unfortunately, as long as US politicians continue putting pot politics before patients' lives, it appears that any potential breakthroughs regarding the potentially curative powers of cannabis will only emerge in a land far from America's shores and beyond the reach of close-minded Washington bureaucrats.

Paul Armentano is the senior policy analyst for the NORML Foundation in Washington, DC. He may be contacted via email at paul@norml.org.

[christophera]

STUDY: SMOKING MARIJUANA DOES NOT
CAUSE LUNG CANCER

Marijuana smoking -"even heavy longterm use"- does not cause cancer of the lung, upper airwaves, or esophagus, Donald Tashkin reported at this year's meeting of the International Cannabinoid Research Society. Coming from Tashkin, this conclusion had extra significance for the assembled drug-company and university-based scientists ( most of whom get funding from the U.S. National Institute on Drug Abuse ). Over the years, Tashkin's lab at UCLA has produced irrefutable evidence of the damage that marijuana smoke wreaks on bronchial tissue. With NIDA's support, Tashkin and colleagues have identified the potent carcinogens in marijuana smoke, biopsied and made photomicrographs of pre-malignant cells, and studied the molecular changes occurring within them. It is Tashkin's research that the Drug Czar's office cites in ads linking marijuana to lung cancer. Tashkin himself has long believed in a causal relationship, despite a study in which Stephen Sidney examined the files of 64,000 Kaiser patients and found that marijuana users didn't develop lung cancer at a higher rate or die earlier than non-users. Of five smaller studies on the question, only two -involving a total of about 300 patients- concluded that marijuana smoking causes lung cancer. Tashkin decided to settle the question by conducting a large, prospectively designed, population-based, case-controlled study. "Our major hypothesis," he told the ICRS, "was that heavy, longterm use of marijuana will increase the risk of lung and upper-airwaves cancers."

The Los Angeles County Cancer Surveillance program provided Tashkin's team with the names of 1,209 L.A. residents aged 59 or younger with cancer ( 611 lung, 403 oral/pharyngeal, 90 laryngeal, 108 esophageal ). Interviewers collected extensive lifetime histories of marijuana, tobacco, alcohol and other drug use, and data on diet, occupational exposures, family history of cancer, and various "socio-demographic factors." Exposure to marijuana was measured in joint years ( joints per day x 365 ). Controls were found based on age, gender and neighborhood. Among them, 46% had never used marijuana, 31% had used less than one joint year, 12% had used 10-30 j-yrs, 2% had used 30-60 j-yrs, and 3% had used for more than 60 j-yrs. Tashkin controlled for tobacco use and calculated the relative risk of marijuana use resulting in lung and upper airwaves cancers. All the odds ratios turned out to be less than one ( one being equal to the control group's chances )! Compared with subjects who had used less than one joint year, the estimated odds ratios for lung cancer were .78; for 1-10 j-yrs, .74; for 10-30 j-yrs, .85 for 30-60 j-yrs; and 0.81 for more than 60 j-yrs. The estimated odds ratios for oral/pharyngeal cancers were 0.92 for 1-10 j-yrs; 0.89 for 10-30 j-yrs; 0.81 for 30-60 j-yrs; and 1.0 for more than 60 j-yrs. "Similar, though less precise results were obtained for the other cancer sites," Tashkin reported. "We found absolutely no suggestion of a dose response." The data on tobacco use, as expected, revealed "a very potent effect and a clear dose-response relationship -a 21-fold greater risk of developing lung cancer if you smoke more than two packs a day." Similarly high odds obtained for oral/pharyngeal cancer, laryngeal cancer and esophageal cancer. "So, in summary" Tashkin concluded, "we failed to observe a positive association of marijuana use and other potential confounders."

There was time for only one question, said the moderator, and San Francisco oncologist Donald Abrams, M.D., was already at the microphone: "You don't see any positive correlation, but in at least one category [marijuana-only smokers and lung cancer], it almost looked like there was a negative correlation, i.e., a protective effect. Could you comment on that?"

"Yes," said Tashkin. "The odds ratios are less than one almost consistently, and in one category that relationship was significant, but I think that it would be difficult to extract from these data the conclusion that marijuana is protective against lung cancer. But that is not an unreasonable hypothesis."

Abrams had results of his own to report at the ICRS meeting. He and his colleagues at San Francisco General Hospital had conducted a randomized, placebo-controlled study involving 50 patients with HIV-related peripheral neuropathy. Over the course of five days, patients recorded their pain levels in a diary after smoking either NIDA-supplied marijuana cigarettes or cigarettes from which the THC had been extracted. About 25% didn't know or guessed wrong as to whether they were smoking the placebos, which suggests that the blinding worked. Abrams requested that his results not be described in detail prior to publication in a peer-reviewed medical journal, but we can generalize: they exceeded expectations, and show marijuana providing pain relief comparable to Gabapentin, the most widely used treatment for a condition that afflicts some 30% of patients with HIV.

To a questioner who bemoaned the difficulty of "separating the high from the clinical benefits," Abrams replied: "I'm an oncologist as well as an AIDS doctor and I don't think that a drug that creates euphoria in patients with terminal diseases is having an adverse effect." His study was funded by the University of California's Center for Medicinal Cannabis Research.
http://www.mapinc.org/drugnews/v05/n1065/a03.html?323

[christophera]

Study Finds No Cancer-Marijuana Connection

By Marc Kaufman
Washington Post Staff Writer
Friday, May 26, 2006; A03



The largest study of its kind has unexpectedly concluded that smoking marijuana, even regularly and heavily, does not lead to lung cancer.

The new findings "were against our expectations," said Donald Tashkin of the University of California at Los Angeles, a pulmonologist who has studied marijuana for 30 years.

"We hypothesized that there would be a positive association between marijuana use and lung cancer, and that the association would be more positive with heavier use," he said. "What we found instead was no association at all, and even a suggestion of some protective effect."

Federal health and drug enforcement officials have widely used Tashkin's previous work on marijuana to make the case that the drug is dangerous. Tashkin said that while he still believes marijuana is potentially harmful, its cancer-causing effects appear to be of less concern than previously thought.

Earlier work established that marijuana does contain cancer-causing chemicals as potentially harmful as those in tobacco, he said. However, marijuana also contains the chemical THC, which he said may kill aging cells and keep them from becoming cancerous.

Tashkin's study, funded by the National Institutes of Health's National Institute on Drug Abuse, involved 1,200 people in Los Angeles who had lung, neck or head cancer and an additional 1,040 people without cancer matched by age, sex and neighborhood.

They were all asked about their lifetime use of marijuana, tobacco and alcohol. The heaviest marijuana smokers had lighted up more than 22,000 times, while moderately heavy usage was defined as smoking 11,000 to 22,000 marijuana cigarettes. Tashkin found that even the very heavy marijuana smokers showed no increased incidence of the three cancers studied.

"This is the largest case-control study ever done, and everyone had to fill out a very extensive questionnaire about marijuana use," he said. "Bias can creep into any research, but we controlled for as many confounding factors as we could, and so I believe these results have real meaning."

Tashkin's group at the David Geffen School of Medicine at UCLA had hypothesized that marijuana would raise the risk of cancer on the basis of earlier small human studies, lab studies of animals, and the fact that marijuana users inhale more deeply and generally hold smoke in their lungs longer than tobacco smokers -- exposing them to the dangerous chemicals for a longer time. In addition, Tashkin said, previous studies found that marijuana tar has 50 percent higher concentrations of chemicals linked to cancer than tobacco cigarette tar.

While no association between marijuana smoking and cancer was found, the study findings, presented to the American Thoracic Society International Conference this week, did find a 20-fold increase in lung cancer among people who smoked two or more packs of cigarettes a day.

The study was limited to people younger than 60 because those older than that were generally not exposed to marijuana in their youth, when it is most often tried.

© 2006 The Washington Post Company

[gwa]

CHILL THE FUCK OUT.

[christophera]

Study: Smoking Pot Doesn't Cause Cancer--It May Prevent It!
The Greatest Story Never Told

Smoking Cannabis Does Not Cause Cancer Of Lung or Upper Airways, Tashkin Finds;
Data Suggest Possible Protective Effect
By FRED GARDNER

The story summarized by that headline ran in O'Shaughnessy's (Autumn 2005), CounterPunch, and the Anderson Valley Advertiser. Did we win Pulitzers, dude? No, the story was ignored or buried by the corporate media. It didn't even make the "Project Censored" list of under-reported stories for 2005. "We were even censored by Project Censored," said Tod Mikuriya, who liked his shot of wry.

It's not that the subject is trivial. One in three Americans will be afflicted with cancer, we are told by the government (as if it's our immutable fate and somehow acceptable). Cancer is the second leading cause of death in the U.S. and lung cancer the leading killer among cancers. You'd think it would have been very big news when UCLA medical school professor Donald Tashkin revealed that components of marijuana smoke -although they damage cells in respiratory tissue- somehow prevent them from becoming malignant. In other words, something in marijuana exerts an anti-cancer effect.

Tashkin has special credibility. He was the lead investigator on studies dating back to the 1970s that identified the components in marijuana smoke that are toxic. It was Tashkin et al who published photomicrographs showing that marijuana smoke damages cells lining the upper airways. It was the Tashkin lab reporting that benzpyrene -a component of tobacco smoke that plays a role in most lung cancers- is especially prevalent in marijuana smoke. It was Tashkin's data documenting that marijuana smokers are more likely than non-smokers to cough, wheeze, and produce sputum.

Tashkin reviewed his findings April 4 at a conference organized by "Patients Out of Time," a reform group devoted to educating doctors and the public (as opposed to lobbying politicians). Some 30 MDs and nurses got continuing medical education credits for attending.

The National Institute on Drug Abuse supported Tashkin's marijuana-related research over the decades and readily gave him a grant to conduct a large, population-based, case-controlled study that would prove definitively that heavy, long-term marijuana use increases the risk of lung and upper-airways cancers. What Tashkin and his colleagues found, however, disproved their hypothesis. (Tashkin is to marijuana as a cause of lung cancer what Hans Blick is to Iraq's weapons of mass destruction -an honest investigator who set out to find something, concluded that it wasn't there, and reported his results.)

Tashkin's team interviewed 1,212 cancer patients from the Los Angeles County Cancer Surveillance program, matched for age, gender, and neighborhood with 1,040 cancer-free controls. Marijuana use was measured in "joint years" (number of years smoked times number of joints per day). It turned out that increased marijuana use did not result in higher rates of lung and pharyngeal cancer (whereas tobacco smokers were at greater risk the more they smoked). Tobacco smokers who also smoked marijuana were at slightly lower risk of getting lung cancer than tobacco-only smokers.

These findings were not deemed worthy of publication in "NIDA Notes." Tashkin reported them at the 2005 meeting of the International Cannabinoid Research Society and they were published in the October 2006 issue of Cancer Epidemiology Biomarkers & Prevention. Without a press release from NIDA calling attention to its significance, the assignment editors of America had no idea that "Marijuana Use and the Risk of Lung and Upper Aerodigestive Tract Cancers: Results of a Population-Based Case-Control Study" by Mia Hashibe1, Hal Morgenstern, Yan Cui, Donald P. Tashkin, Zuo-Feng Zhang, Wendy Cozen, Thomas M. Mack and Sander Greenland was a blockbuster story.

I suggested to Eric Bailey of the L.A. Times that he write up Tashkin's findings -UCLA provided the local angle if the anti-cancer effect wasn't enough. Bailey said his editors wouldn't be interested for some time because he had just filed a marijuana-related piece (about the special rapport Steph Sherer of Americans for Safe Access enjoyed with some old corporado back in Washington, D.C.) The Tashkin scoop is still there for the taking!

Investigators from New Zealand recently got widespread media attention for a study contradicting Tashkin's results. "Heavy cannabis users may be at greater risk of chronic lung disease -including cancer- compared to tobacco smokers," is how BBC News summed up the New Zealanders' findings. The very small size of the study -79 smokers took part, 21 of whom smoked cannabis only- was not held against the authors. As conveyed in the corporate media, the New Zealand study represented the latest word on this important subject (as if science were some kind of tennis match and the truth just gets truthier with every volley).

Tashkin criticized the New Zealanders' methodology in his talk at Asilomar: "There's some cognitive dissonance associated with the interpretation of their findings. I think this has to do with the belief model among the investigators and -I wish they were here to defend themselves- the integrity of the investigators... They actually published another paper in which they mimicked the design that we used for looking at lung function."

Tashkin spoke from the stage of an airy redwood chapel designed by Julia Morgan. He is pink-cheeked, 70ish, wears wire-rimmed spectacles. "For tobacco they found what you'd expect: a higher risk for lung cancer and a clear dose-response relationship. A 24-fold increase in the people who smoked the most... What about marijuana? If they smoked a small or moderate amount there was no increased risk, in fact slightly less than one. But if they were in the upper third of the group, then their risk was six-fold... A rather surprising finding, and one has to be cautious about interpreting the results because of the very small number of cases (14) and controls (4)."

Tashkin said the New Zealanders employed "statistical sleight of hand." He deemed it "completely implausible that smokers of only 365 joints of marijuana have a risk for developing lung cancer similar to that of smokers of 7,000 tobacco cigarettes... Their small sample size led to vastly inflated estimates... They had said 'it's ideal to do the study in New Zealand because we have a much higher prevalence of marijuana smoking.' But 88 percent of their controls had never smoked marijuana, whereas 36% of our controls (in Los Angeles) had never smoked marijuana. Why did so few of the controls smoke marijuana? Something fishy about that!"

Strong words for a UCLA School of Medicine professor!

As to the highly promising implication of his own study -that something in marijuana stops damaged cells from becoming malignant- Tashkin noted that an anti-proliferative effect of THC has been observed in cell-culture systems and animal models of brain, breast, prostate, and lung cancer. THC has been shown to promote known apoptosis (damaged cells die instead of reproducing) and to counter angiogenesis (the process by which blood vessels are formed -a requirement of tumor growth). Other antioxidants in cannabis may also be involved in countering malignancy, said Tashkin.

Much of Tashkin's talk was devoted to Chronic Obstructive Pulmonary Disease, another condition prevalent among tobacco smokers. Chronic bronchitis and emphysema are two forms of COPD, which is the fourth leading cause of death in the United States. Air pollution and tobacco smoke are known culprits. Inhaled pathogens cause an inflammatory response, resulting in diminished lung function. COPD patients have increasing difficulty clearing the airways as they get older.

Tashkin and colleagues at UCLA conducted a major study in which they measured lung function of various cohorts over eight years and found that tobacco-only smokers had an accelerated rate of decline, but marijuana smokers -even if they smoked tobacco as well- experienced the same rate of decline as non-smokers. "The more tobacco smoked, the greater the rate of decline," said Tashkin. "In contrast, no matter how much marijuana was smoked, the rate of decline was similar to normal." Tashkin concluded that his and other studies "do not support the concept that regular smoking of marijuana leads to COPD."

Hope that makes you breathe easier.

Fred Gardner is editor of O'Shaughnessy's. He can be reached at: fred@plebesite.com

[pk-]

they don't give labrats bongs though do they

THC might help combat cancer, but smoking enough of any sort of burning leaves is going to fuck your lungs up

[christophera]

Marijuana may spur new brain cells
Is the US Playing Politics with Pot Research?

Marijuana may help stave off Alzheimer’s
Active ingredient in pot may help preserve brain function

America's Love-Hate Relationship with Drugs

By STEVE MITCHELL
WASHINGTON, Oct. 13 (UPI) -- Scientists said Thursday that marijuana appears to promote the development of new brain cells in rats and have anti-anxiety and anti-depressant effects, a finding that could have an impact on the national debate over medical uses of the drug.

Other illegal and legal drugs, including opiates, alcohol, nicotine and cocaine, have been shown to suppress the formation of new brain cells when used chronically, but marijuana's effect on that process was uncertain.

Now, a team led by Xia Zhang of the department of psychiatry at the University of Saskatchewan in Saskatoon may have found evidence the drug spurs new brain cells to form in a region of the brain called the hippocampus, and this in turn reduces anxiety and depression.

Marijuana appears "to be the only illicit drug whose capacity to produce increased ... neurons is positively correlated with its (anti-anxiety) and anti-depressant-like effects," Zhang and colleagues wrote in the November issue of the Journal of Clinical Investigation. The paper was posted online Thursday.

In the study, rats were given injections of HU210 -- a synthesized version of a cannabinoid chemical found in marijuana -- twice per day for 10 days.

Zhang told United Press International this would be "a high dose" of smoked marijuana, but he added he is not certain how many equivalent joints it would take or whether patients now using the drug typically would be getting this much HU210.

Although HU210 was injected, Zhang said there would be no difference if it was obtained by smoking marijuana.

The rats showed evidence of new neurons in the hippocampus dentate gyrus, a region of the brain that plays a role in developing memories.

Zhang's team suspected the new brain cells also might be associated with a reduction in anxiety and depression, because previous studies had indicated medications used to treat anxiety and depression achieve their effect this way.

To find out, they treated rats with HU210 for 10 days and then tested them one month later. When placed in a new environment, the rats were quicker to eat their food than rats that did not receive the compound, which suggested there was a reduction in anxiety behaviors.

Another group of rats treated with HU210 showed a reduction in the duration of immobility in a forced swimming test, which is an indication the compound had an anti-depressant effect.

Asked how he thought the findings might impact the debate over using marijuana to treat medical conditions, Zhang said, "Our results indicate cannabinoids could be used for the treatment of anxiety and depression."

He added that his view is "marijuana should be used as alcohol or nicotine," noting "it has been used for treating various diseases for years in other countries."

Last June the U.S. Supreme Court voted 6-3 that the federal ban on marijuana supersedes the laws of certain states that allow the substance to be used for medicinal purposes, such as the treatment of pain, nausea in cancer patients and glaucoma. Eleven states have passed laws legalizing marijuana use by patients with a doctor's approval, including California, Alaska, Colorado, Hawaii, Maine, Montana, Nevada, Oregon, Vermont and Washington.

The Bush administration, through the Department of Justice's Drug Enforcement Agency, began conducting raids in California in 2001 on patients using marijuana. Two of those arrested by the DEA -- Angel Raich, who suffers from brain cancer, and Diane Monson, who used the drug to help alleviate chronic back pain -- sued Attorney General John Ashcroft, requesting a court order to be allowed to grow and smoke marijuana, which led to the Supreme Court decision.

Paul Armentano, senior policy analyst with the National Organization for the Reform of Marijuana Laws, told UPI he thought the findings "would have a positive impact on moving forward this debate, because it is giving ... a scientific explanation that further supports long-observed anecdotal evidence, and further lends itself to the notion that marijuana, unlike so many other prescription drugs and controlled substances, appears to have incredibly low toxicity and as a result lacks potential harm to the brain that many of these drugs have."

The DEA Web site, however, contends that "marijuana is a dangerous, addictive drug that poses significant health threats to users," including cancer and impaired mental functioning.

Armentano said this is a distortion of what scientific studies actually show. Studies in animals indicate marijuana actually may protect against many forms of cancer, rather than cause the disease, he said. In addition, studies in marijuana smokers have found little evidence of cognitive deficits, and even when they do, the defects disappear if the person stops smoking for 30 days.

E-mail: sciencemail@upi.com



http://about.upi.com/products/health_bu ... 4854-9860R

Study shows marijuana increases brain cell growth

By Juanita King, The Muse (Memorial University of Newfoundland)
Oct 2005

ST. JOHN’S, Nfld — Supporters of marijuana may finally have an excuse to smoke weed every day. A recent study in the Journal of Clinical Investigation suggests that smoking pot can make the brain grow.

Though most drugs inhibit the growth of new brain cells, injections of a synthetic cannibinoid have had the opposite effect in mice in a study performed at the University of Saskatchewan. Research on how drugs affect the brain has been critical to addiction treatment, particularly research on the hippocampus.

The hippocampus is an area of the brain essential to memory formation. It is unusual because it grows new neurons over a person’s lifetime. Researchers believe these new cells help to improve memory and fight depression and mood disorders.

Many drugs -— heroin, cocaine, and the more common alcohol and nicotine — inhibit the growth of these new cells. It was thought that marijuana did the same thing, but this new research suggests otherwise.

Neuropsychiatrist Xia Zhang and a team of researchers study how marijuana-like drugs — known collectively as cannabinoids — act on the brain.

The team tested the effects of HU-210, a potent synthetic cannabinoid similar to a group of compounds found in marijuana. The synthetic version is about 100 times as powerful as THC, the high-inducing compound loved by recreational users.

The researchers found that rats treated with HU-210 on a regular basis showed neurogenesis — the growth of new brain cells in the hippocampus. A current hypothesis suggests depression may be triggered when the hippocampus grows insufficient numbers of new brain cells. If true, HU-210 could offer a treatment for such mood disorders by stimulating this growth.

Whether this is true for all cannabinoids remains unclear, as HU-210 is only one of many and the HU-210 in the study is highly purified.

“That does not mean that general use in healthy people is beneficial,” said Memorial psychology professor William McKim. “We need to learn if this happens in humans, whether this is useful in healthy people, and whether THC causes it as well.”

McKim warns that marijuana disrupts memory and cognition. “These effects can be long-lasting after heavy use,” he said. “This makes it difficult to succeed academically if you use it excessively.”

“Occasional light use probably does not have very serious consequences. [But] there is some evidence that marijuana smoke might cause cancer.”

Still, the positive aspects of marijuana are becoming more plentiful as further research is done. McKim says it’s not surprising that THC and compounds like it could have medicinal effects.

“Many have been identified,” he said. “It stimulates appetite in people with AIDS, it is an analgesic, and blocks nausea in cancer patients undergoing chemotherapy. And it treats the symptoms of glaucoma.”

The research group’s next studies will examine the more unpleasant side of the drug.
http://www.peak.sfu.ca/the-peak/2005-3/ ... ne-mj.html

[elbe]

This discussed this a few days ago.

I fully accept claims that cannaboids can help prevent cancer, smoking weed will to some extent help prevent cancer, but inhaling burning organic matter, be it the beloved weed plant or not, is not good for your health.

smoking produces Carbon Monoxide, which your blood will substitute for oxygen, Carbon Monoxide sticks to the blood, leaving less room for Oxygen, more you smoke the less Oxygen you get into your blood, less Oxygen in your blood less Oxygen to your brain and other organs, which is not a good thing

[christophera]

they don't give labrats bongs though do they

THC might help combat cancer, but smoking enough of any sort of burning leaves is going to fuck your lungs up

that makes sense if you don't do any research to learn the truth.

you can't count on sweeping dismissals to get you through life.

one day you'll learn to pay attention to details.

[oddfellow]

I think the majority of people smoke it alongside tobacco as well. As this is unfiltered it means a lot more harm is caused.

[christophera]

smoking tobacco is awful and will kill you.

it has nothing to do with pot.

[gwa]

I think the majority of people smoke it alongside tobacco as well. As this is unfiltered it means a lot more harm is caused.

Hardly anyone smokes it with tobacco in america. Its an english / euro thing.

[boomphat]

Bob Marley died of lung cancer.